Pyridine compound and pharmaceutical use thereof

Details Pyridine compound and pharmaceutical use thereof Pyridine compound and pharmaceutical use thereof

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07F 13/00 (2006.01) C07F 15/00 (2006.01)

Patent

CA 2136993

ABSTRACT A pyridine compound of the formula Image (I) wherein R1 is a hydrogen, a halogen, an alkyl, an alkoxy or the like, R2 and R3 are each a hydrogen, a halogen or an alkyl, -P=Q- is -CH=CH-, -N=CH- or -CH=N-, A is an oxygen atom, a sulfur atom or N(R4) wherein R4 is hydrogen, alkyl or the like, n is 0, 1 or 2, B is an oxygen atom, S(O)p wherein p is 0, 1 or 2 or N(R5) wherein R5 is hydrogen or alkyl, D is a single bond, an alkylene or the like and E is an alkoxyalkyl or -N(R6)(R7), and a pharmaceutically acceptable salt thereof have antibacterial activity against Helicobacter pylori, antiulcer activity, gastrointestinal cytoprotective activity, ulcer recurrence or relapse-preventive activity and so on and are useful as pharmaceutical preparations. 8 3

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