Pyridine compounds for treating gpr119 related disorders

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/12 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61P 3/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2660699

The present invention relates to compounds of Formula (Ia) and pharmaceutically acceptable salts, hydrates, geometrical isomers, racemates, tautomers, optical isomers and N-oxides thereof, wherein one of W1 and W2 is N and the other is CR12. The invention also relates to pharmaceutical compositions comprising these compounds, and to the use of these compounds for the prophylaxis and treatment of medical conditions relating to disorders of the G-protein-coupled receptor GPRl 19, such as diabetes and obesity.

L'invention concerne des composés de formule (Ia) et leurs sels, hydrates, isomères géométriques, racémates, tautomères, isomères optiques et N-oxydes pharmaceutiquement acceptables, W1 et W2 représentant N et l'autre représentant CR12. L'invention concerne également des compositions pharmaceutiques renfermant lesdits composés et l'utilisation desdits composés pour la prophylaxie et le traitement de pathologies médicales relatives à des troubles du récepteur de GPR119 couplé à la protéine G, tels que le diabète et l'obésité.

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