Pyridine derivative

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01) A61P 1/16 (2006.01) A61P 1/18 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 15/00 (2006.01) A61P 17/00 (2006.01) A61P 17/02 (2006.01) A61P 17/06 (2006.01) A61P 17/10 (2006.01) A61P 19/06 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01) A61P 27/04 (2006.01) A61P 29/00 (20

Patent

CA 2754446

The present invention relates to a novel pyridine derivative or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the derivative or ester, which has an excellent hypoglycemic effect or treats and/or prevents the onset of a disorder of carbohydrate or lipid metabolism or a disease mediated by peroxisome proliferator-activated receptor (PPAR) .gamma.. A compound represented by the general formula (I): (see formula I) [wherein R represents a pyridyl group substituted with 1 to 3 group(s) independently selected from Substituent Group A, and Substituent Group A represents a halogen atom, a C1-C6 alkyl group and a C1-C6 alkoxy group] or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the compound or ester.

La présente invention concerne un nouveau dérivé de pyridine qui possède une bonne activité hypoglycémique et qui peut traiter des maladies métaboliques du glucose et des lipides ou des maladies associées à un récepteur d'activation et de prolifération des peroxysomes (PPAR) ? et/ou prévenir l'installation de ces maladies, un ester pharmacologiquement acceptable du dérivé de pyridine, ou un sel pharmacologiquement acceptable du dérivé de pyridine ou l'ester pharmacologiquement acceptable. L'invention concerne spécifiquement un composé représenté par la formule générale (I), un ester pharmacologiquement acceptable du composé, ou un sel pharmacologiquement acceptable du composé ou l'ester pharmacologiquement acceptable. [Dans la formule, R représente un groupe pyridyle substitué par 1 à 3 groupes choisis indépendamment à partir d'un groupe substituant A ; et le groupe substituant A consiste en un atome d'halogène, un groupe alkyle en C1 à C6, et un groupe alcoxy en C1 à C6.]

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