Pyridine derivative, anti-ulcer drug, and antibacterial drug

Details Pyridine derivative, anti-ulcer drug, and antibacterial drug Pyridine derivative, anti-ulcer drug, and antibacterial drug

C - Chemistry, Metallurgy

07

D

C07D 213/40 (2006.01) A61K 31/44 (2006.01) C07D 213/60 (2006.01) C07D 213/61 (2006.01)

Patent

CA 2200165

A pyridine derivative or a salt thereof expressed by the following formula 1: (see fig. I) wherein W represents a group expressed by the following formula 2 or formula 3; (see fig. II) (see fig. III) wherein R1 represents an alkenyloxy group; n represents 1 or 2; Ra represents a lower alkyl group; and Rb represents a halogen atom; and wherein each of R2 and R3 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, or halogenated alkyl group; Y represents a group expressed by - S-, - NH- or - CONH-; m represents an integer of 0 to 2; and p represents 0 or 1. The pyridine derivative has an anti-ulcer effect or an antibacterial activity against Helicobacter pyroli to be available for prevention or cure of ulcers.

Dérivé de la pyridine ou sel correspondant, exprimés par la formule I (voir fig. I), où W représente un groupe exprimé par la formule 2 (voir fig. II) ou la formule 3 (voir fig. III), où R1 représente un groupe alcényloxy, n est 1 ou 2, Ra représente un groupe alkyle inférieure et Rb un atome d'halogène, R2 et R3 représentent chacun un atome d'hydrogène, un groupe alkyle inférieur, un groupe alcoxy inférieur ou un groupe alkyle halogéné, Y représente un groupe exprimé par - S-, - NH- ou - CONH-, m représente un entier de 0 à 2, p est 0 ou 1. Le dérivé de la pyridine a un effet antiulcéreux ou une activité antibactérienne vis-à-vis d'Helicobacter pyroli; d'où son utilité pour la prévention ou le traitement des ulcères.

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