C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61K 45/00 (2006.01) A61K 47/36 (2006.01) A61P 1/04 (2006.01) A61P 1/18 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2645467
The object is to provide an excellent pharmaceutical having an anti-Helicobacter pylori activity. Disclosed is a novel pyridine derivative represented by the general formula (I) or a pharmaceutically acceptable salt thereof, which has a potent antibacterial activity against H. pyroli (Helicobacter pyroli): (I) wherein R represents a linear or branched hydroxyalkyl group having 5 to 10 carbon atoms. Examples of the disease which can be prevented/treated by administration of a pharmaceutical agent comprising the compound include gastritis, gastric ulcer, duodenal ulcer, gastric MALT lymphoma, gastric hyperplastic polyp, development of gastric cancer after endoscopic resection of the early stage of gastric cancer and the like.
L'invention concerne un excellent agent pharmaceutique ayant une activité contre Helicobacter pylori qui est un nouveau dérivé de pyridine représenté par la formule générale (I) ou un sel pharmaceutiquement acceptable de celui-ci, et qui a une activité antibactérienne puissante contre H. pylori (Helicobacter pylori) : (I) où R représente un groupe hydroxyalkyle linéaire ou ramifié ayant 5 à 10 atomes de carbone. Des exemples de maladies qui peuvent être prévenues/traitées par l'administration d'un agent pharmaceutique comprenant le composé comprennent la gastrite, l'ulcère gastrique, l'ulcère duodénal, le lymphome gastrique de type MALT, le polype gastrique hyperplasique, le développement d'un cancer gastrique après une résection endoscopique du cancer gastrique à un stade précoce et semblables.
Ito Masaharu
Yamamoto Masaichi
Arigen Pharmaceuticals Inc.
Ridout & Maybee Llp
LandOfFree
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