C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/277
C07D 401/12 (2006.01) A61K 31/435 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 417/00 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 1265138
65702-288 ABSTRACT Novel pyridine derivatives of formula Image (wherein R1 and R2 are H, alkyl, alkoxy, halogenated alkyl, alkoxy- carbonyl, carboxyl or halogen; X is -O-, -S or -NR3- [where R3 is H, alkyl, phenyl, benzyl or alkoxycarbonyl], Z is O(CH2)pOR4 [where R4 is H, alkyl, aryl or aralkyl and p is 1 to 3], -O(CH2)qR5 [where R5 is halogen, alkoxycarbonyl, aryl or heteroaryl and q is 1 to 3], -O(CH2)rO(CH2)SOR6 [where R6 is H or alkyl and r and s are 1 to 5:1], Image [where t is 0 to 2 and A is Image (where B is -NH-, -O- or S-), alkyl, alkoxycarbonylmethyl, pyridyl, furyl or - Image (where R7 is H, alkyl, alkoxy or halogen and w is 0 or 1)], Image [where R8 is acetoxy or alkyl] or -OR9 [where R9 is H, alkyl, aryl or aralkyl] , n is 0 to 2 and m is 2 to 10, J and K are H or alkyl, with the proviso that m is 3 to 10 when Z is OR9 and R9 is alkyl) exhibit activity in treating or preventing peptic ulcers. In one example of a compound of the invention, R1 and R2 65702-288 are both hydroyen, X is a group of formula -NH-, n is zero. J is a methyl group, K is a hydrogen atom, m is 2 and Z is a benzyloxy group.
551684
Fujimoto Masatoshi
Fujisaki Hideaki
Kaneko Toshihiko
Miyazawa Shuhei
Murakami Manabu
Eisai Co. Ltd.
Smart & Biggar
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