Pyridine derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 417/12 (2006.01) A61K 31/44 (2006.01) C07D 417/14 (2006.01)

Patent

CA 1286297

ABSTRACT PYRIDINE DERIVATIVES The present invention provides compounds of formula (1):- Image (1) and pharmaceutically acceptable salts thereof; where A1 is halogen, nitro, amino, C1-6alkyl or C3-4alkoxy; A2 is hydrogen, halogen, nitro, amino, C1-6alkyl or C3-4alkoxy; m is 3 or 4; A3 is hydrogen, C1-6alkyl or CH2A4 wherein A4 is phenyl, pyridyl, N-oxopyridyl or pyrimidinyl, each optionally substituted by C1-6alkyl, C1-6alkoxy, halogen or (with the exception of N-oxopyridyl) hydroxy. The compounds are useful as histamine H1-antagonists.

511117

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