Pyridine derivatives

Details Pyridine derivatives Pyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61P 9/00 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2711803

Compounds of formula (I) in free or salt or solvate form, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

L'invention porte sur des composés représentés par la formule (I) sous forme libre ou de sel ou de solvate, dans laquelle T1, T2, X, Ra, Rb, R8 et R9 ont les significations telles qu'indiquées dans la description. Ces composés sont utiles pour traiter des voies aériennes inflammatoires ou obstructives, une hypertension pulmonaire, une fibrose pulmonaire, une fibrose du foie, des maladies musculaires et des troubles squelettiques systémiques. L'invention porte également sur des compositions pharmaceutiques qui contiennent les composés et sur des procédés pour préparer les composés.

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