Pyridine derivatives and methods of use thereof

Details Pyridine derivatives and methods of use thereof Pyridine derivatives and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) C07D 471/04 (2006.01) C07D 491/048 (2006.01)

Patent

CA 2696725

Disclosed herein are pyridine derivatives, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, pharmaceutical compositions comprising the same, and methods of modulating the level or activity of HIF in a subject, inhibiting hydroxylation of HIF .alpha. in a subject, modulating expression of HIF - regulated genes in a subject, treating an HIF-related disorder in a subject, increasing levels of endogenous EPO in a subject, or treating a disorder in a subject, using the disclosed compounds.

L'invention porte sur des dérivés de pyridine, ou sur un sel, ester, amide ou promédicament pharmaceutiquement acceptable de ceux-ci, sur des compositions pharmaceutiques les comprenant et sur des procédés de modulation du taux ou de l'activité de HIF chez un sujet, d'inhibition de l'hydroxylation de HIF a chez un sujet, de modulation de l'expression des gènes régulés par HIF chez un sujet, de traitement d'un trouble lié à HIF chez un sujet, d'augmentation des taux d'EPO endogène chez un sujet, ou de traitement d'un trouble chez un sujet, à l'aide des composés décrits.

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