Pyridine derivatives as fast dissociating dopamine 2...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/12 (2006.01) A61K 31/44 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2682668

The present invention relates to (1-benzyl-piperidin-4-yl)-(pyridin-2-yl)-amines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.

La présente invention porte sur des (1-benzyl-pipéridine-4-yl)-(pyridine-2-yl)-amine qui sont des antagonistes des récepteurs D2 de la dopamine à dissociation rapide, sur des procédés de préparation de ces composés, et sur des compositions pharmaceutiques comprenant ces composés comme ingrédient actif. Les composés trouvent utilité comme médicaments pour le traitement ou la prévention de troubles du système nerveux central, par exemple la schizophrénie, en exerçant un effet antipsychotique sans effets secondaires moteurs.

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