C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/75 (2006.01) A61K 31/4418 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) A61P 17/00 (2006.01) A61P 25/00 (2006.01) A61P 31/00 (2006.01) C07D 401/12 (2006.01) C07F 9/58 (2006.01)
Patent
CA 2418389
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to inhibitors of ZAP70. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders. These compounds have the general formula: (Ia), (Ib), (Ic) and (Id).
La présente invention concerne des inhibiteurs de p38, une protéine kinase mammalienne impliquée dans la prolifération cellulaire, la mort cellulaire et une réponse à des stimuli extracellulaires. Cette invention concerne également des inhibiteurs de ZAP70, ainsi que des méthodes de production de ces inhibiteurs. Ladite invention a aussi trait à des compositions pharmaceutiques renfermant les inhibiteurs susmentionnés et des méthodes d'utilisation de ces compositions dans le traitement et la prévention de divers troubles.
Bemis Guy
Cochran John
Galullo Vincent
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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