Pyridine derivatives as vegfr-2 receptor and protein...

Details Pyridine derivatives as vegfr-2 receptor and protein... Pyridine derivatives as vegfr-2 receptor and protein...

C - Chemistry, Metallurgy

07

D

C07D 213/75 (2006.01) A61K 31/44 (2006.01) A61K 31/443 (2006.01) A61K 31/444 (2006.01) A61P 17/00 (2006.01) A61P 27/00 (2006.01) A61P 35/00 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2734551

The invention relates to compounds of general formula (I) wherein W, D, E, G, J, L, R1, R2, R3, R4, R5 and Y are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use -alone or in combination with one or more other pharmaceutically active compounds- in therapy, for treating diseases associated with deregulated angiogenesis, such as cancer and skin and eye diseases.

Linvention concerne des composés de la formule générale (I) dans laquelle W, D, E, G, J, L, R1, R2, R3, R4, R5 et Y sont tels que définis dans la description, et des sels, des hydrates ou des solvates pharmaceutiquement acceptables de ceux-ci, pour utilisation, seuls ou en association avec un ou plusieurs composés pharmaceutiquement actifs, en thérapie pour le traitement de maladies associées à une angiogenèse déréglée telle que le cancer ou des maladies cutanées ou oculaires.

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