A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/496 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01) C07D 295/18 (2006.01)
Patent
CA 2580860
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I), where x, y, G, J, K, L, M, W, V, R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
L'invention concerne des procédés de traitement de maladie ou d'affection à médiation assurée par stéaroyl-CoA désaturases (SCD) chez un mammifère, de préférence un humain : administration au mammifère d'un composé de formule (I), dans laquelle x, y, G, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 et R8a sont tels que définis aux fins de la description. On décrit aussi des compositions pharmaceutiques comprenant les composés en question.
Kamboj Rajender
Kodumuru Vishnumurthy
Gowling Lafleur Henderson Llp
Xenon Pharmaceuticals Inc.
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