Pyridine derivatives, process for preparing the same, and...

Details Pyridine derivatives, process for preparing the same, and... Pyridine derivatives, process for preparing the same, and...

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/4709 (2006.01) A61K 31/495 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) A61K 31/695 (2006.01) A61P 11/06 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2224635

The present invention is directed to a pyridine derivative of the formula (I): (see formula I) wherein A is group of the following formulae: (see formula II) (R1 and R2 are each H, or protected or unprotected OH, R31, R41 and R42 are protected or unprotected hydroxymethyl, R32 is H, lower alkyl, or protected or unprotected hydroxymethyl, R33 is substituted or unsubstituted lower alkyl, and the dotted line means the presence or absence of a double bond), R5 and R6 are H, or protected or unprotected amino, or both combine together with the adjacent nitrogen to form substituted or unsubstituted heterocycle, or a pharmaceutically acceptable salt thereof. These compounds showing excellent bronchoconstriction inhibitory activity and/or airway anti-inflammatory activity, and are useful in the prophylaxis or treatment of asthma.

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