Pyridine derivatives, their preparation and their use

Details Pyridine derivatives, their preparation and their use Pyridine derivatives, their preparation and their use

C - Chemistry, Metallurgy

07

D

167/211, 260/296

C07D 213/66 (2006.01) A61K 31/44 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01)

Patent

CA 1288102

ABSTRACT OF THE DISCLOSURE: Disclosed are novel pyridine derivatives of the formula Image (I) where R1 is hydrogen or hydroxyl, R2 is hydroxymethyl, R3 is dimethylaminomethyl, pyrrolidinomethyl, piperidinomethyl or m o r p h o l i n o m e t h y l, or R2 and R3 together may furthermore form the group -CH2-O-CH2-, where a hydrogen atom may be replaced by hydroxyl or methoxy, and R4 is n- propyl, isopropyl or n-butyl, and its salts with physiologically tolerated acides. These derivatives are useful for the therapy of cardiac arrhythmias.

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