C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/4353 (2006.01) A61K 31/4427 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 29/00 (2006.01) C07D 213/09 (2006.01) C07D 213/10 (2006.01) C07D 213/73 (2006.01) C07D 213/80 (2006.01) C07D 213/85 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 471/18 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2422923
Pyridine compounds of general formula (I) wherein -R1 represents, or in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1- 6 alkylsulfonylamino, C1-6 alkoxycarbonyl, C1-6 alkylamino, di (C1-6 alkyl)amino, C1-6 alkanoylamino, phenyl C1-6 alkylamino, phenylsulfonylamino, or -O-(CH2)n-R111 ; R2 represents hydrogen or halogen; R3 represents hydrogen, -CR31R32R33, or -NR34R35; R4 is hydrogen, carbamoyl, CN, carboxyl, etc.; R5 is amino, C1-6 alkylamino, di C1-6 alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
Cette invention concerne des composés de pyridine représentés par la formule générale (I), ou un sel de ces composés. Dans cette formule -R?1¿ représente (A), dans laquelle R?11¿ est hydrogène, alkyle en C¿1-6?, halogène, hydroxy, alkoxy en C¿1-12?, nitro, amino, alkylsulfonylamino en C¿1-6?, alkoxycarbonyl en C¿1-6?, alkylamino en C¿1-6?, di (C¿1-6? alkyl)amino, alkanoylamino en C¿1-6?, phényle C¿1-6? alkylamino, phénylsulfonylamino, ou -O-(CH¿2?)¿n?-R?111¿; R?2¿ représente hydrogène or halogène; R?3¿ représente hydrogène, -CR?31¿R?32¿R?33¿, ou -NR?34¿R?35¿; R?4¿ est hydrogène, carbamoyle, CN, carboxyle, etc.; R?5¿ est amino, alkylamino en C¿1-6?, di C¿1-6? alkylamino, etc. Ce composé présente, parmi d'autres activités biologiques, une remarquable activité anti-inflammatoire.
Fuchikami Kinji
Kadono Hiroshi
Komura Hiroshi
Koriyama Yuji
Lowinger Timothy B.
Aktiengesellschaft Bayer
Bayer Schering Pharma Aktiengesellschaft
Fetherstonhaugh & Co.
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