Pyridine matrix metalloproteinase inhibitors

Details Pyridine matrix metalloproteinase inhibitors Pyridine matrix metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/80 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61P 9/00 (2006.01) A61P 19/00 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2434982

Selective MMP-13 inhibitors are pyridine derivatives of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 independently are hydrogen, halo, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, NO2, NR4R5, CN, or CF3; E is independently O or S; A and B independently are OR4 or NR4R5; R4 and R5 independently are H, C1-C6 alkyl, C2- C6 alkenyl, C2-C6 alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, (CH2)n heteroaryl, or R4 and R5 when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring containing carbon atoms and optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted; n is 0 to 6.

L'invention concerne des inhibiteurs de MMP-13 (métalloprotéinase matricielle) qui sont des dérivés pyridiniques de formule (I), ou un sel de ceux-ci, acceptable au plan pharmaceutique. Dans ladite formule (I), R?1¿ et R?2¿ représentent indépendamment hydrogène,halo, hydroxy, alkyle C¿1?-C¿6?, alcoxy C¿1?-C¿6?, alcényle C¿2?-C¿6?, alcynyle C¿2?-C¿6?, NO¿2?, NR?4¿R?5¿, CN ou CF¿3? ; E représente indépendamment O ou S ; A et B représentent indépendamment OR?4¿ ou NR?4¿R?5¿ ; R?4¿ et R?5¿ représentent indépendamment H, alkyle C¿1?-C¿6?, alcényle C¿2?-C¿6?, alcynyle C¿2?-C¿6?, (CH¿2?)¿n?aryle, (CH¿2?)¿n?cycloalkyle, (CH¿2?)¿n?hétéroaryle, ou R?4¿ et R?5¿ lorsqu'ils sont pris ensemble avec l'azote auquel ils sont attachés, complètent un cycle à 3 à 8 éléments, contenant des atomes de carbone, et contenant éventuellement un hétéroatome choisi parmi O, S ou NH et éventuellement substitué ou pas ; n vaut 0 à 6.

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