A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4412 (2006.01) A61K 31/4418 (2006.01) A61P 31/12 (2006.01) C07D 213/89 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2527586
The present invention relates to pyridinone derivatives of formula (I) wherein Z represents C2-6 alkynyl, aryl or heteroaryl, any of which groups may be optionally substituted, and R1 represents hydrogen, C1-6alkyl, C3-7 heterocycloalkyl(C1-6)alkyl, di(C1-6)alkylamino(C1-6)alkyl, C2-6 alkylcarbonyloxy(C1-6)alkyl or C3-7 cycloalkoxycarbonyloxy(C1-6)alkyl, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C virus infections.
La présente invention concerne des dérivés de pyridinone représentés par la formule (I) dans laquelle Z représente C¿2-6 ?alkynyle, aryle ou hétéroaryle, l'un quelconque de ces groupes pouvant être éventuellement substitués, et R?1¿ représente hydrogène, C¿1-6 ?alkyle, C¿3-7? hétérocycloalkyle, (C¿1-6?)alkyle, di(C¿1-6?)alkylamino(C¿1-6?)alkyle, C¿2-6? alkylcarbonyloxy(C¿1-6?)alkyle ou C¿3-7? cycloalkoxycarbonyloxy(C¿1-6?)alkyle, ainsi que des sels pharmaceutiquement acceptables de ces composés, qui conviennent pour la prévention et le traitement d'infections par le virus de l'hépatite C.
Colarusso Stefania
Narjes Frank
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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