Pyridine/pyrazine-2-carboxamide derivatives and uses thereof

Details Pyridine/pyrazine-2-carboxamide derivatives and uses thereof Pyridine/pyrazine-2-carboxamide derivatives and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/497 (2006.01) A61P 3/10 (2006.01) A61P 5/48 (2006.01) A61P 15/18 (2006.01) A61P 17/14 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2508042

The present invention relates to new compounds of formula (I) wherein: Z is N and X is CH or N; Y is CONR5; P is phenyl or a 5 or 6 membered heteroaromatic ring containing one or more heteroatoms selected from N, O or S; Q is phenyl or a 5 or 6 membered aromatic heterocyclicc ring containing one or more nitrogen atoms;R is C1-6alkylNR10R11 or C1-6alkylazetidine; R10 is hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C0-6alkylC3- 6cycloalkyl, C0-6alkylaryl, C0-61alkylheteroaryl or C1-6alkylNR8R9; R11 is C1-6aIkyINR8R9, C0-6alkylC3-6cycloalkyl or C0-6alkylhetero- cycloalkyl; as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.

La présente invention concerne de nouveaux composés représentés par la formule I dans laquelle Z est N et X est CH ou N; Y est CONR¿5?; P est phényle ou un noyau hétéroaromatique à 5 ou 6 chaînons contenant un ou plusieurs hétéroatomes sélectionnés parmi N, O ou S; Q est phényle ou un noyau hétéroaromatique à 5 ou 6 chaînons contenant un ou plusieurs atomes d'azote;R est alkyle C¿1-6? NR?10¿R?11¿ ou alkylazétidine C¿1-6?; R?10¿ est hydrogène, alkyle C¿1-6?, alcényle C¿2-6?, alcynyle C¿2-6?, alkyle C¿0-6 ?cycloalkyle C¿3-6?, alkylaryle C¿0-6?, alkylhétéroaryle C¿0-6 ?ou alkyle C¿1-6? NR?8¿R?9¿;? ¿R?11 ¿est alkyle C¿1-6? NR?8¿R?9¿, alkyle C¿0-6 ?cycloalkyle C¿3-6 ?ou alkylhétérocycloalkyle C¿0-6?, lesdits composés étant utilisés en tant que base libre. L'invention concerne également un sel, un solvate ou un solvate de sel acceptables d'un point de vue pharmaceutique desdits composés, un procédé de préparation de ceux-ci et de nouveaux intermédiaires utilisés dans la préparation, des formulations pharmaceutiques contenant lesdits composés thérapeutiquement actifs, et l'utilisation desdits composés actifs en thérapie. ?¿

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