C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/02 (2006.01) A61K 31/44 (2006.01) C07D 213/75 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2508165
The invention provides novel pyridines, pharmaceutical compositions comprising such pyridines, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord in one embodiment, the compounds, compositions, and methods of the instant invention treat a mammalian nerve tissue injury by restoring action potential or nerve impulse conduction through a nerve tissue lesion. Significantly, in vivo application of compounds of the instant invention established, on the basis of SSEP testing, that the compounds provide longer lasting effects at lower concentrations than comparable treatment with the known agent 4-aminopyridine (4 AP).
Nouvelles pyridines, compositions pharmaceutiques contenant ces pyridines et utilisation de ces compositions pour traiter des tissus nerveux mammaliens lésés, dont, entre autres, des lésions de la moelle épinière. Dans un mode de réalisation, les composés, compositions et méthodes selon la présente invention permettent de traiter une lésion des tissus nerveux mammaliens par restauration du potentiel d'action ou de la conduction de l'impulsion nerveuse à travers une lésion desdits tissus. De manière significative, l'application in vivo de composés selon la présente invention a permis d'établir, sur la base du test du potentiel évoqué somesthésique, que lesdits composés produisent des effets plus prolongés à de faibles concentrations que le traitement comparable avec l'agent connu 4-aminopyridine (4 AP).
Borgens Richard B.
Byrn Stephen R.
Shi Riyi
Smith Daniel T.
Purdue Research Foundation
Sim & Mcburney
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