C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/74 (2006.01) A61K 31/14 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2553328
The invention relates to compounds having formula I, which block the biosynthesis of phosphorylcholine by selectively blocking the choline kinase enzyme in tumour cells or in cells affected by parasitic infection and which, as a result, can be used in the treatment of tumours and parasitic diseases or diseases caused by viruses and fungi in animals including humans. The invention also relates to a method of preparing the aforementioned compounds and to some intermediates resulting from said method.
L'invention concerne des composés de formule générale (I) qui bloquent la biosynthèse de phosphorylcholine par blocage sélectif de l'enzyme choline kinase dans des cellules tumorales ou dans des cellules affectées par une infection parasitaire et qui, de ce fait, peuvent être utilisés dans le traitement de tumeurs et de maladies parasitaires ou provoquées par un virus ou par des champignons chez des animaux, y compris des êtres humains. L'invention concerne également une méthode de préparation desdits composés et de certains intermédiaires obtenus au moyen de ladite méthode.
Campos Rosa Joaquin
Espinosa Ubeda Antonio
Gallo Meza Miguel Angel
Lacal Sanjuan Juan Carlos
Consejo Superior de Investigaciones Cientificas
Fetherstonhaugh & Co.
Universidad de Granada
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