Pyridinium derivatives

Details Pyridinium derivatives Pyridinium derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/82 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2114183

ABSTRACT The present invention relates to novel pyridinium derivatives of formula I Image W- wherein R1 represents C1-6 alkyl or aryl-1-6 alkyl; R2 represents aryl; Z is -O- or -NR3-; T is -O-, -NR4- or a single bond; R represents C1-18 alkyl, C1-18 haloalkyl, aryl, heteroaryl, aryl-C1-6 alkyl or heteroaryl-C1-6 alkyl, and in addition, when T represents a single bond, R can also represent a phenyl or phenylmethyl radical substituted in the para or meta position by a 2- quinolylmethoxy group; R3 and R4 independently represent hydrogen, C1-4 alkyl, aryl or C1-4 alkylcarbonyl, and in addition, R3 and R4 may form a ring together when Z= NR3 and T= NR4, or R3 may be bonded to R to form a ring when Z= NR3; and W- is a counter anion. These compounds are PAF antagonists.

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