Pyridino[1,2-a]pyrimidin-4-one compounds as anticancer agents

Details Pyridino[1,2-a]pyrimidin-4-one compounds as anticancer agents Pyridino[1,2-a]pyrimidin-4-one compounds as anticancer agents

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01) C07D 221/00 (2006.01) C07D 239/00 (2006.01)

Patent

CA 2528771

Pyridino[1,2.-a]pyrimidinyl compounds of formula (I), pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically.acceptable carrier and one or more of the pyridino[1,2- a]pyrimidinyl compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the pyridino[1,2-a]pyrirnidinyl compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.

La présente invention concerne des composés de pyridino[1,2-a]pyrimidinyle, des sels de ceux-ci, acceptables d'un point de vue pharmaceutique, ainsi que des promédicaments de ceux-ci. La présente invention concerne également des compositions comprenant un support acceptable d'un point de vue pharmaceutique et un ou plusieurs composés de pyridino[1,2-a]pyrimidinyle, soit seuls, soit combinés à au moins un agent thérapeutique supplémentaire. En outre, cette invention concerne des procédés pour utiliser les composés de pyridino[1,2-a]pyrimidinyle soit seuls, soit combinés à au moins un agent thérapeutique supplémentaire, afin de prévenir ou de traiter des maladies prolifératives.

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