C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/02 (2006.01) A61K 31/4985 (2006.01) A61K 31/50 (2006.01) C07D 237/14 (2006.01) C07D 403/14 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2653529
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
L'invention porte sur des composés de formule (I) et leurs sels ou tautomères pharmacocompatibles, inhibiteurs de la poly (ADP-ribose) polymérase (PARP), et s'avérant de ce fait utiles pour traiter: le cancer, les maladies inflammatoires, les lésions de reperfusion, les ischémies, les attaques, l'insuffisance cardiaque, les maladies cardiovasculaires, et vasculaires non cardiovasculaires, le diabète sucré, les maladies neurodégénératives, les infections rétrovirales, les lésions de la rétine, la sénescence de la peau, et les lésions de la peau par les UV, et par les chimio ou radiosensibilisateurs du traitement du cancer.
Bufi Laura Llauger
Ferrigno Federica
Jones Philip
Kinzel Olaf
Pescatore Giovanna
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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