C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/02 (2006.01) A61K 31/4412 (2006.01) A61P 37/00 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2760151
The present invention provides compounds that are alpha4 integrin antagonists having a structure according to the following formula (I) or a tautomer, mixture of tautomers, salt or solvate thereof, wherein Cy, ring A, m, n, p, R1, R2, R3, R4, R5 and R6 are defined in the specification. The invention further provides pharmaceutical compositions including the compounds of the invention as well as methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various conditions and disorders, such as Crohn's disease and ulcerative colitis.
La présente invention concerne des composés qui sont des antagonistes d'intégrines alpha-4 ayant une structure représentée selon la formule (I) suivante, ou un tautomère, un mélange de tautomères, un sel ou un solvate desdits composés. Dans la formule (I), Cy, le cycle A, m, n, p, R1, R2, R3, R4, R5 et R6 sont tels que définis dans la description. L'invention concerne en outre des compositions pharmaceutiques comprenant les composés de l'invention ainsi que des procédés de préparation et d'utilisation des composés et compositions de l'invention, par exemple, dans le traitement et la prévention d'affections et troubles divers, tels que la maladie de Crohn et la rectocolite hémorragique.
Konradi Andrei
Wone David
Xu Ying-Zi
Yuan Shendong
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Elan Pharmaceuticals Inc.
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