C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/435 (2006.01) A61K 31/506 (2006.01) A61P 11/06 (2006.01) C07D 403/12 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2640665
This invention is directed generally to substituted pyridinone and pyrimidinone compounds that generally inhibit p38 kinase, TNF, and/or cyclooxyge.pi.ase activity. Such substituted pyridinone and pyrimidinone compounds include compounds generally corresponding in structure to the following formula: wherein Z, n, R1, R2a, R2b, R2c, R2d, R2e, R3a, R3b R3c, R3d, R4, R5, R6, R7a, R7b, R7c, R7d and R7e are as defined in this specification. This invention also is directed to compositions of such substituted pyridinones and pyrimidinones (particularly pharmaceutical compositions), and methods for treating disorders (typically pathological disorders) associated with p38 kinase activity, TNF activity, and/or cyclooxygenase-2 activity.
L'invention concerne de manière générale des composés pyridinone et pyrimidinone substitués qui ont pour action générale d'inhiber l'activité de la kinase p38, du facteur de nécrose tumorale TNF et/ou de la cyclooxygénase. De tels composés incluent des composés dont la structure répond de manière générale à la formule suivante, dans laquelle Z, n, R1, R2a, R2b, R2c, R2d, R2e, R3a, R3b R3c, R3d, R4, R5, R6, R7a, R7b, R7c, R7d et R7e sont tels que définis dans la description. L'invention concerne également des compositions comprenant lesdits composés pyridinone et pyrimidinone substitués (en particulier des compositions pharmaceutiques) ainsi que des procédés visant à traiter des troubles (typiquement des troubles pathologiques) associés à l'activité de la kinase p38, du TNF et ou de la cyclooxygénase-2.
Devadas Balekudru
Hartmann Susan Joyce
Heier Richard Frederick III
Jerome Kevin Dewayne
Kolodziej Stephen Anthony
Pfizer Products Inc.
Torys Llp
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