Pyridinyl thiadiazolyl- and oxadiazolyl derivatives

Details Pyridinyl thiadiazolyl- and oxadiazolyl derivatives Pyridinyl thiadiazolyl- and oxadiazolyl derivatives

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/44 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2089767

A compound of formula I <See formula I> wherein Z1 is oxygen or sulphur; Z2 is oxygen or sulphur; R is straight or branched C1-15-alkyl substituted with one halogen, -CF3. -OH, -CN, one phenyl, phenoxy, benzoyl or benzyloxycarbonyl groups which aromatic groups are optionally substituted with halogen or -CN, or a 5 or 6 membered heterocyclic group containing one to three N, O or S atom(s) being saturated, partly saturated or aromatic; provided that when Z2 is S and Z1 is O then R cannot be benzyl, or a salt thereof with a pharmaceutically acceptable acid. The invention also also relates to a method of preparing the compounds and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.

Affiliated with

Also associated with

Rating

Pyridinyl thiadiazolyl- and oxadiazolyl derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyridinyl thiadiazolyl- and oxadiazolyl derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyridinyl thiadiazolyl- and oxadiazolyl derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1622527