Pyrido-1,2,4-thiadiazine and pyrido-1,4-thiazine...

C - Chemistry – Metallurgy – 07 – D

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C07D 513/04 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2241565

Pyrido-1,2,4-thiadiazine and -1,4-thiazine derivatives represented by formula (I) wherein A, B, D, R1, R2, R3 and R4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, pulmonary system, the gastrointestinal system and the endocrinological system.

Dérivés de pyrido-1,2,4-thiadiazine et 1,4-thiazine représentés par la formule (I) dans laquelle A, B, D, R?1¿, R?2¿, R?3¿ et R?4¿ sont définis dans la description, leurs compositions et procédés de préparation des composés. Les composés sont utiles dans le traitement de maladies du système nerveux central, du système cardiovasculaire, du système pulmonaire, du système gastro-intestinal et du système endocrinien.

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