Pyrido(2,1-a)isoquinoline derivatives as dpp-iv inhibitors

Details Pyrido(2,1-a)isoquinoline derivatives as dpp-iv inhibitors Pyrido(2,1-a)isoquinoline derivatives as dpp-iv inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/445 (2006.01) A61P 3/10 (2006.01) C07D 221/00 (2006.01) C07D 455/06 (2006.01)

Patent

CA 2471262

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.

La présente invention se rapporte à des composés de formule (I), dans laquelle R<sp>1</sp>, R<sp>2</sp>, R<sp>3</sp>, R<sp>4</sp>, R<sp>5</sp> et R<sp>6</sp> sont tels que définis dans le descriptif et les revendications, ainsi qu'à leurs sels pharmaceutiquement acceptables. Les composés sont utilisés dans le traitement et/ou la prévention de maladies associées au DPP-IV, notamment le diabète, et plus particulièrement le diabète non insulino-dépendant, et d'une altération de la tolérance au glucose.

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