Pyrido[2,3-b]pyrazine-8-substituted compounds and their use

Details Pyrido[2,3-b]pyrazine-8-substituted compounds and their use Pyrido[2,3-b]pyrazine-8-substituted compounds and their use

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01)

Patent

CA 2709257

The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin-8- substituted compounds, as described herein, which, inter alia, inhibit RAF (e.g., B RAF) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit RAF (e.g., BRAF) activity, to inhibit receptor tyrosine kinase (RTK) activity, to inhibit cell proliferation, and in the treatment of diseases and disorders that are ameliorated by the inhibition of RAF, RTK, etc., proliferative disorders such as cancer (e.g., colorectal cancer, melanoma), etc.

La présente invention concerne généralement le domaine des composés thérapeutiques destinés au traitement des troubles prolifératifs, du cancer, etc. L'invention concerne plus spécifiquement certains composés pyrido[2,3-b]pyrazine substitués en position 8, tels que décrits ici, qui,entre autres, inhibent l'activité du RAF (par exemple, le RAF B). La présente invention concerne également des compositions pharmaceutiques comprenant de tels composés, et l'utilisation de tels composés et compositions, à la fois in vitro et in vivo, afin d'inhiber l'activité du RAF (par exemple, le RAF B), d'inhiber l'activité du récepteur de la tyrosine kinase (RTK), d'inhiber la prolifération cellulaire, et dans le traitement de maladies et de troubles qui sont soulagés par l'inhibition du RAF, du RTK, etc., des troubles prolifératifs tels que le cancer (par exemple, le cancer colorectal, le mélanome), etc.

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