Pyrido [2, 3-b] pyrazine and [1, 8] -naphthyridine...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/4985 (2006.01)

Patent

CA 2646128

The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt form thereof, wherein A, L1, R1, R2, R3, R4, R5, R6, and X are as defined herein. The compounds of Formula I have ALK and/or c-Met inhibitory activity, and may be used to treat ALK- or c-Met-mediated disorders or conditions.

L'invention concerne un composé de formule (I) ou un de ses sels pharmaceutiquement acceptables, dans laquelle A, L1, R1, R2, R3, R4, R5, R6 et X sont spécifiés dans la description. Les composés de formule (I) présentent une activité d'inhibition de ALK et/ou de c-Met, et peuvent être utilisés dans le traitement d'états pathologiques ou de troubles médiés par ALK ou c-Met.

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