C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 3/00 (2006.01)
Patent
CA 2614443
The present invention is concerned with compounds of formula (I) wherein R1, R2, R3, R4 and X are as described in the description and claims. The compounds are inhibitors of PTP1B. Accordingly, the compounds can be used for treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
La présente invention concerne des composés représentés par la formule (I) dans laquelle R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP> et X sont tels que décrits dans la description et les revendications. Lesdits composés sont des inhibiteurs de PTP1B. Ces composés peuvent être utilisés, en conséquence, dans le traitement ou la prévention des maladies médiées par PTP-1B, y compris le diabète, l'obésité, et les maladies associées au diabète.
Berthel Steven Joseph
Cheung Adrian Wai-Hing
Kim Kyungjin
Li Shiming
Thakkar Kshitij Chhabilbhai
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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