Pyrido¬2,3-d|pyrimidine and pyrimido¬4,5-d|pyrimidine...

Details Pyrido¬2,3-d|pyrimidine and pyrimido¬4,5-d|pyrimidine... Pyrido¬2,3-d|pyrimidine and pyrimido¬4,5-d|pyrimidine...

A - Human Necessities

61

K

A61K 31/70 (2006.01) C07H 19/00 (2006.01) C07H 19/04 (2006.01)

Patent

CA 2405798

A purine nucleoside analog includes a pyrido[2,3-d]pyrimidine or a pyrimido[4,5-d]pyrimidine and further has a sugar moiety that is optionally modified at the C2', C3', C4' and/or C5' position. Particularly contemplated compounds also include prodrug forms of the purine nucleoside analogs, and both purine nucleoside analogs and the corresponding prodrugs are employed in the reduction of growth of neoplastic cells.

Analogue nucléoside de purine comprenant une pyrido[2,3-d]pyrimidine ou une pyrimido[4,5-d]pyrimidine ainsi qu'une entité sucre modifiée, le cas échéant, en position C2', C3', C4' et/ou C5' position. Des composés plus particulièrement considérés comprennent également des formes de promédicaments d'analogues nucléosides de la purine ; les analogues nucléosides de la purine et les promédicaments correspondants sont employés dans la réduction de la croissance de cellules néoplastiques.

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