Pyrido 2,3-d pyrimidine derivatives

Details Pyrido 2,3-d pyrimidine derivatives Pyrido 2,3-d pyrimidine derivatives

A - Human Necessities

61

K

167/219, 260/242

A61K 31/505 (2006.01) C07D 471/04 (2006.01)

Patent

CA 1276637

ABSTRACT OF THE DISCLOSURE Pyrido[2,3-d]pyrimidines of the formula: Image IA wherein R1 is amino or hydroxy; and R3 is hydrogen, methyl, or ethyl; the configuration about the carbon atom designated * being L; (ib) 5,6,7,8-tetrahydropyrido[2,3-d]- pyrimidines of the formula: Image IB wherein R1 is amino or hydroxy; and R3 is hydrogen, methyl, or ethyl; the configuration about the carbon atom designated * being L; (ii) the tautomeric forms thereof; and (iii) the pharmaceutically acceptable alkali metal, alkaline earth metal, non-toxic metal, ammonium, and substituted ammonium salts thereof are disolosed. These compounds are useful in combatting neoplastic growth.

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