Pyrido [2, 3-d] pyrimidines and their use as kinase inhibitors

Details Pyrido [2, 3-d] pyrimidines and their use as kinase inhibitors Pyrido [2, 3-d] pyrimidines and their use as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2665384

The present invention provides derivatives of pyrido [2,3-d]pyrimidin-7-one of formula (I). These compounds are kinase inhibitors, including compounds that show antiproliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

La présente invention concerne des dérivés de pyrido[2,3-d]pyrimidin-7-one de formule (I). Ces composés sont des inhibiteurs de kinases, comprenant des composés qui présentent une activité antiproliférative, y compris contre des cellules tumorales, et ils sont utiles dans le traitement de maladies dont le cancer.

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