Pyrido ¬2,3-d|pyrimidines derivatives

Details Pyrido ¬2,3-d|pyrimidines derivatives Pyrido ¬2,3-d|pyrimidines derivatives

C - Chemistry, Metallurgy

07

D

260/242.5

C07D 471/04 (2006.01)

Patent

CA 1308411

ABSTRACT OF THE DISCLOSURE A compound of the formula: Image wherein R1 is amino or hydroxy; R3 is hydrogen, methyl, or ethyl; and Z is hydroxy, alkoxy, or -NH-C*(COOX)-CH2CH2COOX in which X is hydrogen or alkyl and the configuration about the carbon atom designated * is L. These compounds are useful as intermediates in making pyrido[2,3-d]pyrimidines of the formula: Image IA wherein R1 is amino or hydroxy; and R3 is hydrogen, methyl, or ethyl; the configuration about the carbon atom designated being L; (ib) 5,6,7,8-tetrahydropyrido[2,3-d]- pyrimidines of the formula: Image IB wherein R1 is amino or hydroxy; and R3 is hydrogen, methyl, or ethyl; the configuration about the carbon atom designated * being L; (ii) the tautomeric forms thereof; and (iii) the pharmaceutically acceptable alkali metal, alkaline earth metal, non-toxic metal, ammonium, and substituted ammonium salts thereof are disclosed.

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