Pyrido[4,3-b]indoles containing rigid moieties

Details Pyrido[4,3-b]indoles containing rigid moieties Pyrido[4,3-b]indoles containing rigid moieties

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/444 (2006.01) A61P 25/00 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2742320

This disclosure is directed to pyrido[4,3-b]indoles having rigid moieties. The compounds in one embodiment are pyrido[4,3-b]indoles having an unsaturated hydrocarbon moiety. The compounds in another embodiment are pyrido[4,3-b]indoles having a cycloalkyl, cycloalkenyl or heterocyclyl moiety. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

Cette invention concerne des pyrido[4,3-b]indoles contenant des fragments rigides. Dans un mode de réalisation, les composés sont des pyrido[4,3-b]indoles contenant un fragment hydrocarboné insaturé. Dans un autre mode de réalisation, les composés sont des pyrido[4,3-b]indoles contenant un fragment cycloalkyle, cycloalcényle ou hétérocyclyle. L'invention concerne également des compositions pharmaceutiques comprenant les composés, ainsi que des procédés d'utilisation des composés dans diverses applications thérapeutiques, notamment le traitement d'un trouble cognitif, d'un trouble psychotique, d'un trouble médié par un neurotransmetteur et/ou d'un trouble neuronal.

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