Pyrido[4,3-d]pyrimidinone derivatives as kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2711937

The invention provides a class of compounds of Formula (I), pharmaceutical com-positions comprising such compounds and meth-ods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZA-P70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC, IGR-IR, AIk, c-FMS, or combina-tions thereof.

L'invention concerne une classe de composés représentés par la formule (I), des compositions pharmaceutiques contenant desdits composés et des procédés d'utilisation desdits composés pour traiter ou prévenir des maladies ou des troubles associés à une activité kinase anormale ou dérégulée, en particulier, de Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC, IGR-1R, Alk, c-FMS, ou des combinaisons de celles-ci.

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