Pyrido-pyridazinone and pyridazinthione compounds

Details Pyrido-pyridazinone and pyridazinthione compounds Pyrido-pyridazinone and pyridazinthione compounds

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/50 (2006.01) C07C 69/76 (2006.01) C07D 213/79 (2006.01) C07D 213/80 (2006.01) C07D 237/32 (2006.01)

Patent

CA 2117059

Benzo or pyridopyridazinones and pyridazinthiones of formula (I) wherein: X and Y are nitrogen or carbon, provided that at least one is carbon, and Z is oxygen or sulfur; R1 is hydrogen, lower alkyl, aryl, heteroaryl, or heterocycle lower alkylene; R2, R3, R4, R5 and R6 are independently selected from hydrogen, lower alkyl, halo, carboxy, alkoxycarbonyi, carbamoyl, aryl, acyl halide, thiomethyl, trilluoromethyl, cyano or nitro; or a pharmaceutically acceptable ester, ether or salt thereof, have been found to be useful as an anti-inflammatory, antiasthmatic, immunosuppressive, anti-allograft rejection, anti- graft-vs-host rejection, autoimmune disease or analgetic agent(s).

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