Pyrido-pyrido pyrimidine derivatives, preparation thereof,...

Details Pyrido-pyrido pyrimidine derivatives, preparation thereof,... Pyrido-pyrido pyrimidine derivatives, preparation thereof,...

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2572614

The invention concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I), in the form of a base or an addition salt to a pharmaceutically acceptable acid, in the form of hydrates or solvates, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The invention also concerns a method for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.

L'invention à pour objet des dérivés de pyrido[2,3-d]pyrimidine, leur préparation et leur application en thérapeutique, de formule générale (I) qui suit : Formule (I) à l'état de base ou de sel d'addition à un acide pharmaceutiquement acceptable, à l'état d'hydrates ou de solvats, ainsi que sous forme d'énantiomères, de diastéréoisomères et leur mélange. L'invention a également pour objet leur procédé de préparation, des compositions pharmaceutiques contenant un composé de formule générale (I), et leur utilisation dans le traitement du cancer.

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