Pyridone derivatives

Details Pyridone derivatives Pyridone derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/444 (2006.01) A61P 1/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 15/00 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 25/08 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 25/30 (2006.01) A61P 25/32 (2006.01) A61P 27/06 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2479141

A compound represented by the general formula (I): (I) (wherein R1 means hydrogen, halogeno, cyano, lower alkyl, lower haloalkyl, hydroxy, lower alkoxy, or aralkyloxy; R2 and R3 each independently means hydrogen, halogeno, or lower haloalkyl; and R4 and R5 each independently means hydrogen or halogeno) and the like. The compounds are useful as a therapeutic agent for various diseases in which NPY participates, e.g., overeating, obesity, and diabetes.

L'invention concerne un composé représenté par la formule générale (I), (dans laquelle R?1¿ représente hydrogène, halogéno, cyano, alkyle inférieur, haloalkyle inférieur, hydroxy, alcoxy inférieur, ou aralkyloxy; R?2¿ et R?3¿ représentent chacun indépendamment hydrogène, halogéno, ou haloalkyle inférieur; et R?4¿ et R?5¿ représentent chacun indépendamment hydrogène ou halogéno), et analogue. Les composés sont d'utiles agents thérapeutiques contre diverses maladies dans lesquelles NPY participe, par exemple l'hyperphagie, l'obésité et les diabètes.

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