Pyridone esters as inotropic agents

Details Pyridone esters as inotropic agents Pyridone esters as inotropic agents

C - Chemistry, Metallurgy

07

D

167/207, 260/250

C07D 213/78 (2006.01) C07C 45/70 (2006.01) C07C 49/175 (2006.01) C07D 213/80 (2006.01) C07D 213/85 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 413/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1247618

ABSTRACT OF THE DISCLOSURE Described are compounds of the formula Image wherein R is hydrogen, lower alkyl, halo, cyano, hydroxy, amino, lower alkylamino, -CH2NH2, -CH2OH or -COOR"; R' is is hydrogen, lower cycloalkyl or lower alkyl; R" is lower alkenyl, lower alkynyl, lower cycloalkyl, -(W)nY wherein W is straight or branched chain lower alkyl or lower alkenyl, n is 0 to 5, and Y is Ar, lower cycloalkyl, lower alkenyl, lower alkynyl, -COOZ wherein Z is lower alkyl, Image , or NAB wherein A and B are, independently, lower alkyl, benzyl or substituted benzyl, and Ar is 2,3 or 4-pyridyl, pyridazinyl, pyrimidinyl, quinolyl, isoquinolyl, phthalazinyl, 1uinazolinyl, thiazolyl, phenyl, benzyl, furyl, tetra- hydrofuryl or thienyl, unsubstituted or substituted with lower alkyl, lower aldoxy, halo, amino, or -CF3; R''' is -COOR", Image and X is oxygen or nitrogen; or a pharmaceutically acceptable salt thereof, and their use in the treatment of impaired ventricular myocardial contractility. The compounds exhibit cardiotonic activity.

485774

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