C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/044 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01) A61K 31/535 (2006.01) C07D 491/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2247018
Pyridonecarboxylic acid derivatives of general formula (I); esters and salts of the derivatives; drugs containing them; and bicyclic amines which are direct intermediates for the derivatives (wherein R is optionally halogenated cycloalkyl or the like; X is hydrogen, lower alkyl, amino or the like; Y is hydrogen or halogeno; A is nitrogen or C-Z (wherein Z is optionally halogenated lower alkoxy or the like); R1 and R2 are each independently hydrogen or the like; R3 is hydrogen or lower alkyl; R4, R5, R6, R7, R8 and R9 are each independently hydrogen, halogeno or lower alkyl; m is 0 or 1; and n and p are each independently 0 or 1).
L'invention concerne des dérivés d'acide pyridonecarboxylique de la formule générale (I), des esters et des sels desdits dérivés, des médicaments les contenant ainsi que des amines bicycliques constituant des intermédiaires directs desdits dérivés, formule dans laquelle R représente cycloalkyle facultativement halogéné ou analogue, X représente hydrogène, alkyle inférieur, amino ou analogue, Y représente hydrogène ou halogéno, A représente azote ou C-Z (où Z représente alcoxy inférieur ou analogue facultativement halogéné), R¿1? et R¿2? représentent chacun indépendamment hydrogène ou analogue, R¿3? représente hydrogène ou alkyle inférieur, R¿4?, R¿5?, R¿6?, R¿7?, R¿8? et R¿9? représentent chacun indépendamment hydrogène, halogéno ou alkyle inférieur, m est égal 0 ou 1 et n et p représentent chacun indépendamment 0 ou 1.
Chiba Katsumi
Horiuchi Nobuhiko
Yonezawa Takenori
Yoshida Hiroaki
Dainippon Pharmaceutical Co. Ltd.
Smart & Biggar
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