Pyridopyrazine derivatives

Details Pyridopyrazine derivatives Pyridopyrazine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2194872

Heterobicyclic derivatives of formula (I) wherein R1 is aryl which may have suitable substituent(s), ar(lower)alkyl which may have suitable substituent(s), halo(lower)alkyl, protected carboxy(lower)alkyl, acyl(lower)alkyl, heterocyclic group or heterocyclic(lower)alkyl which may have suitable substituent(s), R2 is aryl which may have suitable substituent(s) or heterocyclic group, and R3 is hydrogen, lower alkoxy or arylthio, and a pharmaceutically acceptable salt thereof which are useful as PDE IV and TNF inhibitors.

Dérivés hétérobicycliques de formule (I) dans laquelle R?1¿ représente aryle pouvant avoir un ou plusieurs substituants appropriés, aryle-alkyle inférieur pouvant avoir un ou plusieurs substituants appropriés, halo-alkyle inférieur, carboxy-alkyle inférieur protégé, acyle-alkyle inférieur, un groupe hétérocyclique ou alkyle inférieur hétérocyclique pouvant avoir un ou plusieurs substituants appropriés; R?2¿ représente aryle pouvant avoir un ou plusieurs substituants appropriés ou un groupe hétérocyclique et R?3¿ représente hydrogène, alcoxy inférieur ou arylthio et sel pharmaceutiquement acceptable desdits dérivés, qui sont utiles en tant qu'inhibiteurs de la phosphodiestérase IV et du facteur de nécrose des tumeurs.

Affiliated with

Also associated with

Rating

Pyridopyrazine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyridopyrazine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyridopyrazine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1419106