Pyridopyrimidine or naphthyridine derivative

Details Pyridopyrimidine or naphthyridine derivative Pyridopyrimidine or naphthyridine derivative

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 3/10 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 15/10 (2006.01)

Patent

CA 2438294

The present invention is directed to a pyridopyrimidine or a naphthyridine derivative of the formula (I): (see formula I) wherein R1 is an optionally substituted nitrogen-containing heterocyclic group, an optionally substituted amino group or an optionally substituted alkoxy group; R2 is a hydrogen atom or a lower alkyl group; R3 is a hydrogen atom, an optionally substituted lower alkyl group or an optionally substituted heteroaryl group; R4 is a hydrogen atom, a lower alkyl group, or an optionally esterified or amidated carboxyl group; R5 is a lower alkyl group which may be optionally substituted by a group selected from an optionally substituted aryl group, an optionally substituted heteroaryl group and a di-lower alkylamino group; and one of X and Y is a group of the formula: =CH- and the other is nitrogen atom, or X and Y are both nitrogen atoms, or a pharmaceutically acceptable salt thereof. These compounds exhibit excellent P DEV inhibitory activities, and are useful in the prophylaxis or treatment of penile erectile dysfunction and other functional disorders of cGMP-signaling.

L'invention concerne un dérivé de pyridopyrimidine ou naphthyridine représenté par la formule générale (I), dans laquelle R<1> est éventuellement un groupe hétérocyclique azoté substitué, etc. ; R<2> est hydrogène ou alkyle inférieur ; R<3> est hydrogène, alkyle inférieur éventuellement substitué, etc. ; R<4> est hydrogène, alkyle inférieur, COOH, etc. ; R<5> est hydrogène, aryle éventuellement substitué, etc. ; et un élément parmi X et Y représente CH et l'autre azote ou bien X et Y représentent tous deux azote, ou un sel pharmaceutiquement acceptable dudit dérivé. Ledit dérivé et son sel présentent une excellente activité inhibitrice de la PDE V et sont utiles en tant que traitement préventif/remède contre la dysérection.

Affiliated with

Also associated with

Rating

Pyridopyrimidine or naphthyridine derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyridopyrimidine or naphthyridine derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyridopyrimidine or naphthyridine derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1474835