C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/505 (2006.01) A61P 25/28 (2006.01) C07D 221/00 (2006.01) C07D 239/00 (2006.01)
Patent
CA 2394525
This invention provides a method for treating neurodegenerative diseases in mammals comprising administering an effective amount of a cyclin-dependent kinase inhibitor. A preferred method uses cdk inhibitors of Formula (I) and Formula (II) where W is NH, S, SO, or SO2, R1 includes phenyl and substituted phenyl, R2 includes alkyl and cycloalkyl, R3 includes alkyl and hydrogen, R8 and R9 include hydrogen and alkyl, and Z is carboxy.
L'invention concerne un procédé permettant de traiter les maladies neurodégénératives chez les mammifères. Ce procédé consiste à administrer une quantité efficace d'un inhibiteur de kinase dépendante des cyclines. Un mode de réalisation optimal consiste à utiliser des inhibiteurs de kinase dépendante des cyclines représentés par la formule (I) et par la formule (II). Dans ces formules, W représente NH, S, SO, ou SO¿2?, R?1¿ comprend un phényle et un phényle substitué, R?2¿ comprend un alkyle et un cycloalkyle, R?3¿ comprend un alkyle et un hydrogène, R?8¿ et R?9¿ comprennent un hydrogène et un alkyle, et Z représente carboxy.
Booth Richard John
Chatterjee Arindam
Malone Thomas Charles
Sim & Mcburney
Warner-Lambert Company
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