A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/675 (2006.01) A61K 31/138 (2006.01) A61K 31/277 (2006.01) A61K 31/34 (2006.01) A61K 31/44 (2006.01) A61K 31/4406 (2006.01) A61K 31/4415 (2006.01) A61K 31/496 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2580970
Methods for treating angina are described. A method. for treating angina is directed to concurrently administering a compound with a therapeutic cardiovascular compound. The combination therapy described employs suitable therapeutic cardiovascular compounds, such as an a calcium channel blocker, a .beta.-adrenergic blocker, nitrates, partial fatty acid oxidation inhibitors, potassium channel activators, or a mixture thereof, in combination with a compound such as pyridoxal-5'~phosphate, pyridoxic acid, pyridoxal, pyridoxine, pyridoxamine, 3-acylated analogues of pyridoxal, 3-acylated analogues of pyridoxal-4,5-aminal, pyridoxine phosphonate analogues, a pharmaceutically acceptable acid addition salt thereof, or a mixture thereof. The invention also includes a novel composition comprising at least one compound and nitrates, partial fatty acid oxidation inhibitors, potassium channel activators, calcium channel blockers, .beta.-adrenergic blockers, or a mixture thereof.
La présente invention décrit des méthodes de traitement d'angines. Une méthode consiste en l'administration simultanée d'un composé spécifique et d'une substance thérapeutique contre les maladies cardiovasculaires. La thérapie combinée décrite emploie des substances thérapeutiques intervenant dans le traitement de maladies cardiovasculaires, telles qu'un agent bloquant le canal calcium, un agent bloquant .beta.-adrénergique, des nitrates, des inhibiteurs partiels d~oxydation des acides gras, des agents activant le canal potassium, ou un mélange de ces substances, associées à un composé tel que le pyridoxal 5~-phosphate, l~acide pyridoxique, le pyridoxal, la pyridoxine, la pyridoxamine, des analogues 3-acylés du pyridoxal, les analogues 3-acylés du pyridoxal-4,5-aminal, des analogues de pyridoxine phosphonate, un sel d~addition acide de qualité pharmaceutique de l~un de ces composés, ou un mélange de ces composés. La présente invention inclut également une nouvelle préparation incluant au moins un composé et des nitrates, des inhibiteurs partiels d~oxydation des acides gras, des agents activant le canal potassium, des agents bloquant le canal calcium, des agents bloquants .beta.-adrénergiques, ou un mélange de ces composés.
Medicure International Inc.
Ridout & Maybee Llp
LandOfFree
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