Pyridoxine derivatives, a process for their preparation and...

C - Chemistry – Metallurgy – 07 – D

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260/207.1, 260/2

C07D 213/67 (2006.01) C07D 209/28 (2006.01) C07D 401/12 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01)

Patent

CA 1190922

ABSTRACT OF THE DISCLOSURE The esters of pyridoxine and of isopropylidene pyridoxine with 1-(p-chlorobenzoyl)-2-methyl-5-methoxy-indol- 3-acetic acid and 5-(2,4-difluorophenyl)-salicyclic acid are essentially endowed with the same activities of the corresponding acids and are less toxic and gastrolesive, whereby the therapeutical index is remarkably improved. For the preparation of these compounds the chloride of the acid is reacted with isopropylidene pyridoxine, followed by a hydrolysis to obtain the corresponding pyridoxine deri- vative.

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