C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01)
Patent
CA 2646952
The present invention provides compounds of the formula (I), or the pharmaceutically acceptable salts thereof, wherein G, W, R2, R3, R4, R5 and R6 are as defined in the specification. Further objects of the invention are processes and intermediates for the preparation of the compounds of the formula (I), pharmaceutical compositions comprising them and methods for treating cell proliferative disorders. As a matter of fact, the compounds of the formula (I) are useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
La présente invention concerne des composés de formule (I) ou les sels acceptables du point de vue pharmaceutique de ceux-ci, dans laquelle G, W, R2, R3, R4, R5 et R6 sont tels que définis dans la description. L'invention concerne également des procédés et des intermédiaires pour la préparation des composés de formule (I), des compositions pharmaceutiques les comprenant et des méthodes pour le traitement de troubles prolifératifs des cellules. Les composés de formule (I) sont utiles, en thérapie, dans le traitement de maladies associées à une activité de protéine kinase dérégulée, comme le cancer.
Caldarelli Marina
Cirla Alessandra
Ermoli Antonella
Forte Barbara
Menichincheri Maria
Nerviano Medical Sciences S.r.l.
Smart & Biggar
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