Pyridyl- and pyrimidyl-piperazines in the treatment of...

A - Human Necessities – 61 – K

Patent

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A61K 31/505 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2253473

Use of a compound of formula (I) and the pharmaceutically acceptable acid addition salts thereof, wherein R1 is either halogen or hydrogen and R2 is halogen; X is CH2, O or S; R3 and R4 are the same or different and selected from hydrogen or lower alkyl; n is 2 or 3; A is selected from the pyrimidyl- or pyridyl- groups (a), (b) or (c) wherein R5, R6 and R7 are as defined in the description; for the manufacture of a medicament for the relief or prevention of a withdrawal syndrome resulting from addiction to a drug or substance of abuse or for treatment thereof.

L'invention porte sur des composés de formule (I) et leurs sels d'addition acides. Dans ladite formule, R1 est halogène ou hydrogène et R2 est halogène; X est CH¿2?, O ou S; R3 et R4 sont identiques ou différents et choisis parmi hydrogène ou alkyle inférieur; n est 2 ou 3; A est choisi parmi les groupes pyrimidyle ou pyridyle de formules (a), (b) ou (c), où R5, R6, R7 sont définis dans la description. Ces composés entrent dans la fabrication de médicaments servant à atténuer ou prévenir le syndrome de privation résultant de la prise de drogues ou de substances intoxicantes ou à le traiter.

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